Nootropics have only been around for the last 50 years or so with the invention of Piracetam. Since then, there has been an exponential increase in nootropics in the scientific community. The vast majority of nootropic development has only taken place within the last 15 years.

As the industry develops, researchers are discovering new nootropic substances every year.

This is a list of all of the new nootropics you need to try, and some of the up and coming research chemicals that we’re likely to see develop in the next 2-5 years.

a man with the notebook


This is an AMPAkine nootropic, which means that it works on the AMPA receptors. This mechanism is similar to how other popular nootropics work, such as the racetams (piracetam, pramiracetam, aniracetam).

Unifiram increases the activity of the neurotransmitter glutamate, giving it mild stimulating effects. This makes it especially useful for increasing focus and concentration.



Coluracetam is a new member to the racetam family of nootropics. This family includes the first nootropics ever developed (Piracetam), which continues to be popular to this day.

This racetam was developed with the intention of being used to treat Alzheimer’s disease. It works by increasing the uptake of choline into the neurons. Once inside, choline is used to build the important neurotransmitter acetylcholine. Coluracetam is believed to improve vision, making colours more vivid, which is what has resulted in its common name (sounds like Colour-Racetam).


Flourenol is an up and coming nootropic, believed to be the replacement for modafinil. It has similar effects to modafinil, which include increasing mental energy, improving memory and learning capacity, and boosting focus and concentration. This class of chemicals is referred to as Eugeroic.

Flourenol is also being investigated for its ability to speed up the recovery process of amphetamine addicts. Flourenol is avilable under the trade name Hydrafinil. It has a shorter duration than Modafinil, but is considered to be around 40% stronger.

New Natural Nootropics

Herbs are one of the main sources of nootropic chemicals, and were some of the first ever discovered. Some of the most well-studied herbal nootropics include rhodiola, bacopa, ginkgo, and ginseng.

Research on herbs for their various traditional uses has lead to a number of them being considered for nootropic benefits.

Peony Glycosides

Peony (Paeonia albiflora) is traditionally used for hormonal dysregulation, arthritis, and cardiovascular disease. Recent research on this herb has identified a set of chemicals aptly named “Peony glycosides” that are useful for increasing neurotransmitter function in the brain, supporting learning and memory. These glycosides have been shown to produce cognitive benefits in animal studies.

Muira Puama

Muira Puama (Ptychopetalum olacoides) is another tree originating from the Amazon rainforest. Its bark contains a set of chemicals with anti acetylcholinesterase activity. This is a common mechanism for nootropic substances for promoting better learning and memory.


Catuaba (Trichilia catigua) is a large tree found in the Amazon rainforest. Local indigenous cultures have been using catuaba bark for treating low libido, and age-related cognitive decline for centuries.

Recently catuaba has seen a surge in popularity among nootropic users for preventing and correcting age-related cognitive decline. Its potent neuroprotective effects are useful for sharpening the mind and reducing mental fatigue when performing mentally tasking activities like cramming for tests, or working late into the night on work projects.

Where To Find New Nootropics

As nootropics are being developed, it can be difficult to find them in the early stages until more people begin demanding these substances from the market. Things like Flourenol are still a few years away, but other nootropics like colouracetam and Unifiram are getting easier to find all the time.

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