Piracetam is an artificial derivative of the neurotransmitter GABA. This drug was first developed by a Belgium laboratory UCB Pharma in 1964 to improve corpus callosum communication. Corpus callosum is the section of the brain that controls all communication between the two parts of the brain. Piracetam is a nootropics drug that belongs to the racetam group and is sold under different brand names. It is a cognitive enhancer supplement that improves cognitive abilities. It is a safe and effective drug that protects overall brain health.

Piracetam is one of the most widely researched smart drugs. Research shows that it not only enhances cognitive abilities in older people but is also effective in younger people. This exceptional nootropics have low insolubility and contagiousness levels and produce very few side effects.  It removes the poisons and toxins from the brain and reduces the damage that is caused by oxidative stress. It is also effective in stroke patients as it reduces the damage caused by the stroke itself.


It is also used in the treatment of dementia, ischemia, and cognitive impairment. Furthermore, this drug contributes to the cognitive enhancement of children suffering from dyspraxia and dyslexia. It is equally useful in patients that have the Down syndrome because it helps in slowing down the rapid aging of the brain. It works as a modulator of neuroplasticity, neuron-protection, and brain metabolism. This drug is equally effective in combatting antiepileptic and anti-seizure effects. Piracetam is also used to decrease the symptoms usually associated with alcohol withdrawal, clinical depression, and anxiety.

Due to its many salient features, this drug is commonly prescribed for people who are new to nootropics. It has been around for more than fifty years which makes it an excellent drug to start with. Piracetam is much less potent than the various nootropics available in the market thus making it a safe choice.

How does Piracetam Work?

Although extensive research has been done on the action mechanism of Piracetam it’s working still remains vague. However, it has been established that it works in the following ways:

  • Protects brain cells from damage and signs of aging.
  • Boosts glucose and oxygen uptake in brain cells that enhance the feelings of mental fluidity and alertness.
  • Improves cellular membrane permeability.
  • Increases cholinergic neurotransmission that helps the working memory and general cognition.

Double-blind placebo-controlled research of Piracetam shows that it improves the dispersal and delivery of oxygen molecules to the brain cells which in turn results in increased circulation of blood to neural tissues. Better circulation is important for healthy and nourished tissues which help to protect against decay as a result of aging and normal damage to the brain. This drug also helps to get rid of waste materials from the cells at a quicker rate.

Cell membrane protects the brain against hypoxia and also reduces the risk of brain damage due to lack of oxygen. Research shows that Piracetam improves the permeability of the cell membrane. It also increases the glucose levels in the brain. This increased metabolism of glucose enhances mental alertness and energy.  This smart drug has also shown to increase CAMP or cyclic adenosine monophosphate which enhances the function of mitochondria, particularly in aging brains.

When a person uses Piracetam, it targets their receptor sites and Acetylcholine (Ach) transmitters. These neurotransmitters are responsible for focus, attention, and memory. Thus taking Piracetam enhances cognitive abilities.

Piracetam directly improves a person’s memory process and development. Increase in oxygen levels, due to the use of this drug, increases brain energy thus leaving the user feeling more motivated and focused.

Brain cells communicate better when the cell membrane is working effectively. As we grow older, the fluid in the brain cell membrane decreases thus affecting the cognitive functions of the brain. Use of Piracetam is said to restore this fluid thus increasing memory and learning. Moreover, it is a great promoter of transfer of information from one part of the brain to the other. Piracetam also enhances motor planning between the two brain hemispheres.

Short and Long-Term Effects and Side Effects

Piracetam is an effective supplement that helps in temporary gains in learning capacities, intelligence boost, and memorization. Furthermore, it has numerous long-term advantages. It reduces the symptoms of brain aging and improves the overall cognition longevity. Users might experience a few common side effects although it is important to note that Piracetam is considered one of the safest nootropics drug with hardly any severe side effects. These common side effects are:

  • Sleepiness
  • Weight gain
  • Headaches
  • Hyperkinesia
  • Shakiness
  • Nervousness
  • Diarrhea
  • Hyperactivity

Additional Information on Piracetam

Regular use of this drug results in various social, physical, and cognitive benefits. Piracetam easily interacts with the Glutamate and Acetylcholine receptors thus enhancing cognition and memory. However, each individual experiences different effects. Some may feel an increase in thought or memory process while some may remember even the slightest details of events. Piracetam increases blood circulation in the brain which enhances focus and concentration. Users of this drug are likely to feel an increase in the ability to pay attention, think, and manipulate data. They can also perform normal tasks such as writing and reading with better mental fluidity.

The most common benefit reported by users is an improvement in memory and learning.  Daily use of this drug greatly improves brain function and working memory. Regular use of Piracetam results in heightened motivation. It favorably affects both physical and mental energy while showing promising results in people suffering from depression. Regular use of this nootropic has also proven to lessen symptoms of social anxiety, sleep disorders, and general anxiety disorders.

Piracetam use also enhances sensory perception thus improving the ability to distinguish small details in touch, smell, and sight. Users have also shown an improvement in the ability to recall past auditory, olfactory, and visual experiences and their connection to other memories. First-time users have also reported an increased vibrancy of colors. Piracetam administration also helps in increasing attention span and reducing fatigue by increasing oxygen utilization by the brain. This smart drug has also been found to have significant benefits for children who have reading disorders.

Piracetam and The Corpus Callosum

Scientists have divided the human brain into two hemispheres – the left-brain is concerned with analytical or academic intelligence that encompasses the ability to speak, process grammar, read and write, and to understand logic, numbers, and analysis while the right-brain is associated with things that relate to imagination, emotion, music, creativity, style, feelings, color, fantasy, recognition of self, personality development and socialization. Piracetam increases the communication between the two parts of the brain and increases the activity of the corpus callosum.


What Is The Chemical Background of Piracetam?

The common chemical name for Piracetam is 2-oxo-1-pyrrolidine acetamide. It has the similar 2-oxo-pyrrolidone base structure as that of 2-oxo-pyrrolidine carboxylic acid.

Piracetam Dosage and Suggested Usage

Piracetam dosage may depend on various factors such as weight, age, and sex of the patient as well as the reason for which it is being administered. The standard dosage is usually 1600 mg given three times a day in the beginning although this may not be applicable to everyone. For children, the dose will be different. Some people feel better results when they take 1-2 pills every hour for 4-6 hours while some feel it advantageous to take 4-8 pills at once in the beginning to notice an effect. This smart drug has not shown any serious side effects even when taken in high doses. People who have been using this drug for a long period of time suggest taking Choline with Piracetam because Choline helps to boost the positive effects associated with Piracetam and eliminates its side effects. Although Choline supplements are readily available in the market, it is also naturally abundant in cauliflower, eggs, and beef liver.

Using Piracetam in A Nootropic Stack

A woman with notebook and coffee

Stacking can greatly increase the effectiveness of any nootropic drug. Due to its very few side effects and low toxicity, Piracetam can be used with prescription drugs, choline sources, other racetams, and cognitive enhancers. The most commonly used nootropic stack of Choline and Piracetam is particularly effective in leveraging receptor actions and specific neurotransmitter. Different racetams have different effects. However, when they are stacked together, they work as a team. For example, Piracetam when taken with Fasoracetam enhances anti-depressive effects or when stacked with Aniracetam it may enhance AMPA receptor functions. You can also stack Piracetam with vitamins and supplements such as B-complex, caffeine, potassium, vinpocetine, and huperzine-A to increase its effectiveness.

Does Piracetam Work?

Piracetam improves, stimulates, and increases the activities of Ach receptors. These receptors send signals throughout the brain and are responsible for focus, attention, and memory. Piracetam enhances the functioning of the brain thus directly affecting an individual’s memory process and development. Regular use of this drug increases oxygen levels which enhance brain energy allowing the users to feel more motivated and focused.


Piracetam is one of the safest nootropics drug available. There are various benefits of this drug and virtually no side effects. It is also safe to stack Piracetam with different vitamins, supplements, and various racetams.