Do you ever have the problem of not getting the fullness of your energy? During the day, you just don’t seem to be a hundred percent, that sleep is taking over your well-being. Though it’s a common problem, in some cases, it could be more severe. Looking into this problem, some sites or specialists may suggest drugs, namely Modafinil, Adrafinil or Armodafinil. So just what exactly are they and do they all do the same thing? Well, you would be surprised that they are referring to different things. Anti-sleep agents that will improve your body in different ways, so what exactly are they?
Modafinil is known to prevent extreme sleepiness and boosts all-around awareness: energy, focus, memory and, in general, making the user more awake. In many countries, Modafinil is known as a prescription drug for narcolepsy — a disorder that affects the control of sleep and wakefulness, usually during the day. Due to this, you’ll need a prescription as it’s classified as medicine for these effects.
Adrafinil is very similar to Modafinil; in fact, it gets converted to Modafinil. Nonetheless, Adrafinil isn’t a prescription drug, so it’s legal to buy and take Adrafinil without any problems in most countries. It should be known that it’ll take longer to show its effectiveness than plain Modafinil because it first needs to be converted, but in the end, it’ll have the same effects.
Armodafinil does treat daytime sleepiness, in fact, it can actually be more effective due to it taking longer to leave for the body. Nonetheless, it’s another drug you would need a prescription for.
Yet there’s a little more than meets the eye...
Armodafinil actually has related pharmacological properties to Modafinil. Armodafinil is known as an enantiomer to Modafinil, commonly called “R-Modafinil. So what is an enantiomer? Well, it’s when a pair of molecules that are mirror images of each other. Modafinil has two different molecules, R-Modafinil and S-Modafinil. The S stands for “sinister” -which in Latin means “left”, and where the R represents “rectus”, or “right”.
Why does that matter, though?
Well, the body’s enzymes react differently to S molecules compared to R molecules. Enzymes usually are usually present either in an S or an R form. Commonly seen as R enzyme, S molecules don’t get along with the enzyme.
Modafinil creates both the R and the S variant that gives us that awake effect people want, however, the R variant lasts longer in the body compared to the S. R-Modafinil, which lasts about 15 hours, compared to S-Modafinil, which has about 4 hours.
Normal Modafinil has an even greater amount of S and R-Modafinil; this is known as a “racemate.” The first five hours are usually the strongest because their half-lives are so different. Of course, after that, S-Modafinil has left the body and is replaced with R-Modafinil. Then, from there, the next seven to ten hours, half of the Modafinil (R-Modafinil) would be in your bloodstream.
Since then, Armodafinil has created to overcome this issue and give the users a more, long-lasting effect that usually lasts twelve to fifteen hours, with no fall-off point. Though making pure R-Modafinil is difficult, it requires some chemical techniques, which are expensive.
For that reason, Armodafinil is the more expensive drug compared to Modafinil.
What are S-Adrafinil and R-Adrafinil, and What They Do
Adrafinil has both S-Adrafinil and R-Adrafinil, which haven’t been separated because no one has been able to make them separate, however, no one really talks about it. Why does it matter? Well, Adrafinil is strongest in the initial five hours but fades slowly from there.
On the other hand, isn’t Adrafinil turned into Modafinil, which lasts a lot longer than a total of ten hours?
Sadly, no one knows a lot about the process of Adrafinil being converted to Modafinil or really anything on Adrafinil, in general. Most of our knowledge about Adrafinil are educated guesses, like how the body reacts to S molecules compared to R molecules, or that the effects are usually five to eight hours long. From there, it’s a hypothesis that the body uses S-Adrafinil,and that most effects come from S-Modafinil, which has a small duration.
It should be noted that this has not been tested or proved a hundred percent true. However, though it would make sense, that doesn’t mean these observations can’t be proven wrong with science.
Hypothetically, if it’s proven true, Adrafinil would be turned into Modafinillic Acid and Sulfone, which don’t actually have the nootropic effects we want, but Sulfone does have anticonvulsant effects. In the body, the molecules get converted into those when Modafinil is cleared out of the bloodstream. It could be that R-Adrafinil has turned those unwanted substances, making S-Adrafinil become S-Modafinil.
What Does Adrafinil Do To Our Bodies
When in the body, Modafinil gets converted into the liver, which concerns some people. Well, Adrafinil does get converted to Modafinil in the liver, but the liver does generate extra enzymes. Similar to Adrafinil, Tylenol also goes to the liver and has the same effect, all because of the enzymes, Modafinil breaks down there too. One of the purposes of the liver is to breakdown molecules in the bloodstream. It only becomes an issue when it’s taken too often or taken to many doses, like many medical drugs.
For that reason, it’s not encouraging taking Adrafinil often.
Another thing to know: if you, or any user, have liver issues, it’s not recommended to take anything that uses the liver. This could increase any problems there, making them worse. In addition, if you take anything daily that uses the liver, then Modafinil will need more processing power as well. Like most issues you have with your health, it’s best to go to your doctor to discuss any issue or concerns you have before taking nootropics.
The warning Modafinil-related articles mention for precautions is: the same enzymes in the liver that break down Adrafinil and Modafinil also break down birth control hormones. This is important because they can clear the hormones from the body faster due to Adrafinil or Modafinil taking the enzymes. If you take hormonal birth control, it’s discouraging to take Adrafinil or Modafinil. If you need to take it, be safe and prepare, use protection just to make sure!
In the end: What’s the best -afinil?
Well, that is all up to you and what you are seeking for your body and way of living! Since this is important to your lifestyle and how to improve it, it’s your choice.
Many people would pick Armodafinil since it sounds the most beneficial, but like most things, it’s not perfect. With the duration being up to fifthteen hours long, that can mess anyone’s sleeping schedule if taken long into the day, possibly leaving you awake until the early AMs. As an anti-sleeping agent, it’ll definitely keep you up, but it’ll also keep you from your sleep, making you more tired in the end.
The best, stress-free option would be Adrafinil because it’s easier to take whenever. Since the duration is shorter, you come take two if you need to and if you timed it right, not affecting your well-deserved sleep when it rolls around. It could even make it easier to motivate some in the late evening.
So what of Modafinil then? Well, since it’s a prescription drug, you would need your doctor to be able to receive and use it, Modafinil is not legal over the counter. Another downside is that the duration is long, and that it starts to become least affected after five to eight hours. However, it does work a little faster, working and kicking in half an hour, compared to Adrafinil, which is about an hour.
Hopefully, you have learned a little more from this article. That this has answered any questions or concerns you may have had, and from here, you’ll pick the one you need wisely. Talk to your doctor and you’ll hopefully make a more informed choice then before this and know what to expect if you try one. It may not be for everyone, however, that they do show results of being effective in most people. Issues with being awake and attentive all the time happen to everyone, and could be dangerous, if it becomes a problem or you have narcolepsy and haven’t tried one of them, it may be time to look into it.